Fast onset of action and the analgesic and sedative efficacy of essential oil from Rhizoma Chuanxiong after nasal administration. Pharmazie. 2010
- Chuanxiong had faster onset of action as well as better analgesic and sedative efficacy after i.n. administration than given orally.
- Oil was collected from the condenser, dried over anhydrous sodium sulfate, and the recorded yield of the sample was 0.25%
Sedative and anticonvulsant activities of styrax after oral and intranasal administration in mice. Pharm Biol. 2011
- styrax had faster onset of action (5 vs. 30 min) and better anticonvulsant efficacy (25, 50 vs. 100, 200 mg/kg) by intranasal route in comparison with that by intragastric route.
- vehicle (3% Tween 80)
- Locomotor activity
- Locomotor activity was determined in each mouse after extract administration.
- Prior to assay, mice were placed into a locomotor monitoring cage and allowed to habituate to the cage for 5min (0–5min after the administration).
- Each mouse was monitored for 1h.
- Data were expressed as number of movements (5–60min) for 10 mice for each group.
- #sedative(진정), #hypnotic(최면), and #anticonvulsant(경련) effects using locomotor activity evaluation, pentobarbital-induced sleeping time, and pentylenetetrazol (PTZ)-induced convulsion, respectively.
- #안식향
Intranasal drugs for analgesia and sedation in children admitted to pediatric emergency department: a narrative review. Ann Transl Med. 2021
- #pediatric #emergency
- midazolam, fentanyl, ketamine, and dexmedetomidine.
- To provide analgesia and anxiolysis to children
Anti-inflammatory and analgesic properties of Heracleum persicum essential oil and hydroalcoholic extract in animal models. J Ethnopharmacol. 2009
- #Essential oil #hydroalcoholic extracts
- In carrageenan test Heracleum persicum essential oil (HPEO) at doses of 100 and 200 mg/kg and Heracleum persicum hydroalcoholic extract (HPHE) at a dose of 400 mg/kg induced a significant reduction of paw edema.
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