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2022.07.22

Odor blocking of stress hormone responses. Sci Rep. 2022

  • Restraint Mice were placed individually in a restrainer (a transparent plastic cylinder)27 located in their home cage for 10 min. The restrainer had a hole in the end near the tip of the animal’s nose. A piece of filter paper (1.5 × 2 cm) with absorbed 50 µL of odorant or VEH (water or DMSO) was placed in the cage near the hole in the cylinder.
  • Predator odor Mice were exposed to a predator odor or distilled water as described previously15. A piece of filter paper (impregnated with 50 µL of 85 mM 2,5-dihydro-2,4,5-trimethylthiazoline (TMT) (Contech) diluted in water) was dropped gently into one end of the home cage. Animals were exposed to filter paper for 10 min.
  • For analysis of c-Fos expression in CRH neurons, adult male C57BL/6J mice were exposed to water or 2PE with restraint for 10 min and then perfused 50 min later.


Effects of Olfactory Stimulation with Aroma Oils on Psychophysiological Responses of Female AdultsInt J Environ Res Public Health. 2022

  • prof. Moon


[research question]

  • Rapid-acting? (강점)비교연구, (약점)알맞은 기전은? 행동분석 간 영향 최소화, PK 
  • long-lasting/sustained effect?
  • Synergy?
  • Drug resistance model?

[meeting w/Oh]

#Tissue distribution #Pharmacokinetics
  • Comparative study of the efficacy and pharmacokinetics of reduning injection and atomization inhalation
#Rapid acting mechanism
  • Yueju Pill Rapidly Induces Antidepressant-Like Effects and Acutely Enhances BDNF Expression in Mouse Brain. 2013
  • Effect of the fragrance inhalation of essential oil from Asarum heterotropoides on depression-like behaviors in mice. 2015


Review paper

#table: human studies vs  pre-clinical examinations

#Summary of the study characteristics

  • e.g. year, Assessment method, Animal model/test subjects, Route of administration, Effective dosage, Mode of preparation, Outcome

#Chmical composition 

  • e.g. The main chemical groups found in EOs are benzenoids, phenylpropanoids, monoterpenoids, and sesquiterpenoids, 

#A detailed description (major essential oils or compounds) 

  • essential oils (or compounds) to increase appetite
  • essential oils (or compounds) to suppress appetite

#Suggestion: limitation, Future Studies

#Graphical abstract

#Conclusions

[ref]

  • Effects of essential oils on central nervous system: Focus on mental health. 2020
  • Therapeutic Effect and Mechanisms of Essential Oils in Mood Disorders: Interaction between the Nervous and Respiratory Systems. 2021
  • The Effect of Acupuncture on Modulating Inflammatory Cytokines in Rodent Animal Models of Respiratory Disease: A Systematic Review and Meta-Analysis. 2022
  • Inhalation Aromatherapy via Brain-Targeted Nasal Delivery: Natural Volatiles or Essential Oils on Mood Disorders. 2022
  • Medical aromatherapy in geriatric syndrome. 2021


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oral vs intranasal

Fast onset of action and the analgesic and sedative efficacy of essential oil from Rhizoma Chuanxiong after nasal administration. Pharmazie. 2010 Chuanxiong had faster onset of action as well as better analgesic and sedative efficacy after i.n. administration than given orally. Oil was collected from the condenser, dried over anhydrous sodium sulfate, and the recorded yield of the sample was 0.25% Sedative and anticonvulsant activities of styrax after oral and intranasal administration in mice. Pharm Biol. 2011 styrax had faster onset of action (5 vs. 30 min) and better anticonvulsant efficacy (25, 50 vs. 100, 200 mg/kg) by intranasal route in comparison with that by intragastric route. vehicle (3% Tween 80)  Locomotor activity  Locomotor activity was determined in each mouse after extract administration.  Prior to assay, mice were placed into a locomotor monitoring cage and allowed to habituate to the cage for 5min (0–5min after the administration).  Each mouse was ...
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