Fast onset of action and the analgesic and sedative efficacy of essential oil from Rhizoma Chuanxiong after nasal administration. Pharmazie. 2010 Chuanxiong had faster onset of action as well as better analgesic and sedative efficacy after i.n. administration than given orally. Oil was collected from the condenser, dried over anhydrous sodium sulfate, and the recorded yield of the sample was 0.25% Sedative and anticonvulsant activities of styrax after oral and intranasal administration in mice. Pharm Biol. 2011 styrax had faster onset of action (5 vs. 30 min) and better anticonvulsant efficacy (25, 50 vs. 100, 200 mg/kg) by intranasal route in comparison with that by intragastric route. vehicle (3% Tween 80) Locomotor activity Locomotor activity was determined in each mouse after extract administration. Prior to assay, mice were placed into a locomotor monitoring cage and allowed to habituate to the cage for 5min (0–5min after the administration). Each mouse was ...
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