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Time of Day # Behavioral T.

Behavioral T._Time of Day

Of the 200 papers examined in the new study, more than half either failed to report the timing of behavioral testing or did so ambiguously. Only 20 percent reported nighttime testing. Many Mouse Studies Happen at the Wrong Time of Day. scientificamerican. 2021


Time-of-day as a critical biological variable. Neuroscience & Biobehavioral Reviews. 2021


If you do decide to run them during the evening hours, you should be careful with how you do it. I wouldn't recommend waiting until their nighttime and testing them under bright white lights - that can cause some problems with the animals' circadian rhythms and may cause any number of unexpected effects. You could test them under red light (which they can't see) and it shouldn't cause any problems, though. Pehrson, Alan. (2014). 

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oral vs intranasal

Fast onset of action and the analgesic and sedative efficacy of essential oil from Rhizoma Chuanxiong after nasal administration. Pharmazie. 2010 Chuanxiong had faster onset of action as well as better analgesic and sedative efficacy after i.n. administration than given orally. Oil was collected from the condenser, dried over anhydrous sodium sulfate, and the recorded yield of the sample was 0.25% Sedative and anticonvulsant activities of styrax after oral and intranasal administration in mice. Pharm Biol. 2011 styrax had faster onset of action (5 vs. 30 min) and better anticonvulsant efficacy (25, 50 vs. 100, 200 mg/kg) by intranasal route in comparison with that by intragastric route. vehicle (3% Tween 80)  Locomotor activity  Locomotor activity was determined in each mouse after extract administration.  Prior to assay, mice were placed into a locomotor monitoring cage and allowed to habituate to the cage for 5min (0–5min after the administration).  Each mouse was ...
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